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Several laboratory projects
focus on elucidating the mechanisms underlying sex/gender factors that influence
disease susceptibility, severity and rate of progression in vascular and renal
disease. We are investigating the role of
sex chromosomes
(XX vs XY) using Sry transgenic mice in models of hypertension and renal
disease as well as the role of ovarian hormones in the aging Dahl
salt-sensitive rat, the renal wrap model of hypertension and the unilateral
ureteral obstruction model of tubulointerstitial fibrosis. Particular emphasis
is placed on sex chromosome and ovarian hormone effects on the activity of the
renin angiotensin system including the newly discovered angiotensin converting
enzyme 2 and angiotensin type 1 receptor (AT1R)
modulation of reactive oxygen species.
Additional projects include
investigating post-transcriptional regulation of the AT1R under
physiological and pathophysiological conditions by alternative splicing,
upstream short open reading frames and RNA secondary structure, and through
nonsense mediated mRNA decay by upstream termination codons.
Applicants should send a CV and
brief description of their research interests to:
Kathryn Sandberg, PhD
Department of Medicine
Suite 232 Building D
4000 Reservoir Road, NW
Washington, DC 20007
Tel: 202 687-4179 (office)
Fax: 202 687-7278
email:
sandberg@georgetown.edu
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